Bioactive scaffolds for bone regeneration

Abstract

Bone tissue engineering has been investigated for decades, and has shown to be an effective method to induce ectopic bone formation in numerous animal models. The translation to, and application in clinical practice is an ongoing challenge, and as a result, tissue engineered bone grafts are not used routinely. The overall aim of this thesis was to improve scaffold architecture and functionality for tissue engineering of bone. The resulting scaffolds can be applied as a model to answer basic scientific questions as well as an important step towards future application of regenerative techniques in clinical practice.