Sorting out Sortilins: structural studies on the VPS10 family
Files
Publication date
2017-11-10
Authors
Leloup, N.O.L.
Editors
Advisors
Supervisors
Gros, Piet
Janssen, B.J.C.
DOI
Document Type
Dissertation
Metadata
Show full item recordCollections
License
Abstract
The topic of this dissertation is the structural characterization of the VPS10 receptors Sortilin and SorCS2, as well as their interactions with proneurotrophins. A multidisciplinary approach is used to better understand how these receptors function, from ligand binding and release to receptor recycling and signal transduction.
Keywords
Sorting, Receptors, Structures, VPS10, Sortilin, SorCS2
Citation
Leloup, N O L 2017, 'Sorting out Sortilins: structural studies on the VPS10 family', Universiteit Utrecht.