Studies on the role of adenovirus E1 genes in transformation and oncogenesis

Abstract

Human adenoviruses are divided into at least three subgroups on the basis of their oncogenicity in hamsters: subgroup A containing highly oncogenic viruses, subgroup B weakly oncogenic viruses, and subgroup C (most of the) nononcogenic viruses. Despite these clear distinctions in oncogenic activity among the three sugroups, all human adenoviruses are capable of transforming cultured cells into tumor-like cells.