Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels
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Publication date
2016-05
Authors
Widagdo, W
Raj, V Stalin
Schipper, Debby
Kolijn, Kimberley
van Leenders, Geert J L H
Bosch, Berend-Jan
Bensaid, Albert
Segalés, Joaquim
Baumgärtner, Wolfgang
Osterhaus, Albert D M E
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Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) is not efficiently transmitted between humans, but it is highly prevalent in dromedary camels. Here we report that the MERS-CoV receptor - dipeptidyl peptidase 4 (DPP4) - is expressed in the upper respiratory tract epithelium of camels but not humans. Lack of DPP4 expression may be the primary cause of limited MERS-CoV replication in the human upper respiratory tract, hence restrict transmission.
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Widagdo, W, Raj, V S, Schipper, D, Kolijn, K, van Leenders, G J L H, Bosch, B J, Bensaid, A, Segalés, J, Baumgärtner, W, Osterhaus, A D M E, Koopmans, M P, van den Brand, J M A & Haagmans, B L 2016, 'Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels', Journal of Virology, vol. 90, no. 9, pp. 4838-4842. https://doi.org/10.1128/JVI.02994-15