Prognostic models for predicting the severity and mortality in people with acute pancreatitis

Abstract

This is a protocol for a Cochrane Review (Prognosis). The objectives are as follows: The primary objective is to synthesise available evidence from external validation studies evaluating the predictive accuracy of clinical scoring systems (measured on admission and up to 48 hours following admission) for severity and mortality within six months in people with acute pancreatitis. The secondary objective is to compare different risk thresholds of available scoring systems (i.e. the level at which the risk of severe acute pancreatitis or mortality is considered to be high) to predict severity and mortality within six months in people with acute pancreatitis. For both objectives, we will explore differences in patient populations, length of follow-up, and study design as potential sources of between-study heterogeneity.