Lion (Panthera leo) and cheetah (Acinonyx jubatus) IFN-y sequences
Publication date
2010
Authors
Maas, Miriam
van Rhijn, I.
Allsopp, M.T.
Rutten, V.P.M.G.
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Advisors
Supervisors
Document Type
Article
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taverne
Abstract
Cloning and sequencing of the full length lion and cheetah interferon-gamma (IFN-γ) transcript will enable the expression of the recombinant cytokine, to be used for production of monoclonal antibodies and to set up lion and cheetah-specific IFN-γ ELISAs. These are relevant in blood-based diagnosis of bovine tuberculosis, an important threat to lions in the Kruger National Park. Alignment of nucleotide and amino acid sequences of lion and cheetah and that of domestic cats showed homologies of 97–100%.
Keywords
IFN-γ, Sequence, Lion, Cheetah, Mycobacterium bovis, Feline, Taverne, SDG 3 - Good Health and Well-being
Citation
Maas, M, van Rhijn, I, Allsopp, M T & Rutten, V P M G 2010, 'Lion (Panthera leo) and cheetah (Acinonyx jubatus) IFN-y sequences', Veterinary Immunology and Immunopathology, vol. 134, no. 3-4, pp. 296-298. https://doi.org/10.1016/j.vetimm.2009.10.001