Linkage study of 14 candidate genes and loci in four large Dutch families with vesico-ureteral reflux
Publication date
2007
Authors
Eerde, A.M. van
Koeleman, B.P.C.
Kamp, J.M. van de
Jong, T.P.V.M. de
Wijmenga, C.
Giltay, J.C.
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DOI
Document Type
Article
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Abstract
Vesico-ureteral reflux (VUR) is a major contributing
factor to end-stage renal disease in paediatric patients.
Primary VUR is a familial disorder, but little is known
about its genetic causes. To investigate the involvement of
12 functional candidate genes and two reported loci in
VUR, we performed a linkage study in four large, Dutch,
multi-generational families with multiple affected individuals.
We were unable to detect linkage to any of the genes
and loci and could exclude the GDNF, RET, SLIT2, SPRY1,
PAX2, AGTR2, UPK1A and UPK3A genes and the 1p13
and 20p13 loci from linkage to VUR. Our results provide
further evidence that there appears to be genetic heterogeneity
in VUR.
Keywords
Vesico-ureteral reflux/genetics, Kidneydiseases/genetics, Kidney diseases/pathology, Linkage (genetics)