Log In

Are renal ciliopathies (replication) stressed out?

Files

00653_main.pdf (323.05 KB)

Publication date

2015-06

Authors

Slaats, Gisela G.ORCID 0000-0002-4567-0134
Giles, Rachel H.ISNI 0000000398612082

Editors

Advisors

Supervisors

DOI

https://doi.org/10.1016/j.tcb.2015.03.005

Document Type

Article

Metadata

Show full item record

Collections

UMC Repository
Open Access logo

License

taverne

Abstract

Juvenile renal failure is commonly caused by the ciliopathy nephronophthisis (NPHP). Since all NPHP genes regulate cilia function, it has been assumed that NPHP onset is due to cilia loss. However, recent data suggest that DNA damage caused by replication stress, possibly concomitant with or upstream of cilia dysfunction, causes NPHP.

Keywords

Taverne, Journal Article, Research Support, Non-U.S. Gov't, Review

Citation

Slaats, G G & Giles, R 2015, 'Are renal ciliopathies (replication) stressed out?', Trends in Cell Biology, vol. 25, no. 6, pp. 317-9. https://doi.org/10.1016/j.tcb.2015.03.005

URI

https://dspace.library.uu.nl/handle/1874/332915