Low-molecular-weight heparin and aspirin use in relation to pregnancy outcome in women with systemic lupus erythematosus and antiphospholipid syndrome: A cohort study
Publication date
2017-02
Authors
Abheiden, Carolien N H
Blomjous, Birgit S.
Kroese, Sylvia J.
Bultink, Irene E M
Fritsch-Stork, Ruth D E
Lely, A Titia
de Boer, Marjon A.
de Vries, Johanna I P
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Advisors
Supervisors
Document Type
Article
Metadata
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cc_by_nc_nd
Abstract
Objective: To relate anticoagulant use to pregnancy complications in women with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS). Methods: All ongoing pregnancies, 184, in two Dutch tertiary centers between 2000 and 2015. Results: LMWH and aspirin was prescribed in 15/109 SLE women without antiphospholipid antibodies (aPL), 5/14 with aPL, 11/13 with APS, 45/48 with primary APS. Main complications in the four treatment groups (no anticoagulant treatment, aspirin, LMWH, aspirin and LMWH) included hypertensive disorders of pregnancy (9.4%, 23.3%, 50%, 18.4%, respectively, p = 0.12) and preterm birth (16.7%, 34.3%, 75%, 36.8%, respectively, p <0.001). Conclusion: Maternal and perinatal complications occurred frequently, despite LMWH and aspirin use.
Keywords
Antiphospholipid syndrome, aspirin, hypertensive disorders of pregnancy, low-molecular-weight heparin, systemic lupus erythematosus, Internal Medicine, Obstetrics and Gynaecology, Journal Article
Citation
Abheiden, C N H, Blomjous, B S, Kroese, S J, Bultink, I E M, Fritsch-Stork, R D E, Lely, A T, de Boer, M A & de Vries, J I P 2017, 'Low-molecular-weight heparin and aspirin use in relation to pregnancy outcome in women with systemic lupus erythematosus and antiphospholipid syndrome : A cohort study', Hypertension and Pregnancy, vol. 36, no. 1, pp. 8-15. https://doi.org/10.1080/10641955.2016.1217337