Proton-detected solid-state NMR detects the inter-nucleotide correlations and architecture of dimeric RNA in microcrystals
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Publication date
2017-10-26
Authors
Yang, Yufei
Xiang, Shengqi
Liu, Xiaodan
Pei, Xiaojing
Wu, Pengzhi
Gong, Qingguo
Li, Na
Baldus, M.
Wang, Shenlin
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Abstract
We report a novel proton-detected MAS solid-state NMR strategy based on 15N–15N proton assisted recoupling to detect the inter-nucleotide NH⋯N hydrogen bonds within the Watson–Crick base pairs of micro-crystallized dimeric RNA and to confirm the kissing-loop structure. This would contribute to advances in the structural determination of RNA using solid-state NMR.
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Yang, Y, Xiang, S, Liu, X, Pei, X, Wu, P, Gong, Q, Li, N, Baldus, M & Wang, S 2017, 'Proton-detected solid-state NMR detects the inter-nucleotide correlations and architecture of dimeric RNA in microcrystals', Chemical Communications, vol. 53, no. 96, pp. 12886-12889. https://doi.org/10.1039/C7CC07483B