Cost-effectiveness of screening program for chronic q fever, the netherlands
Files
Publication date
2020-02
Authors
De Boer, Pieter T.
De Lange, Marit M.A.
Wielders, Cornelia C.H.
Dijkstra, Frederika
van Roeden, Sonja E.
Bleeker-Rovers, Chantal P.
Oosterheert, Jan J.
Schneeberger, Peter M.
Van Der Hoek, Wim
Editors
Advisors
Supervisors
Document Type
Article
Metadata
Show full item recordCollections
License
Abstract
In the aftermath of a large Q fever (QF) epidemic in the Netherlands during 2007-2010, new chronic QF (CQF) patients continue to be detected. We developed a health-economic decision model to evaluate the cost-effectiveness of a 1-time screening program for CQF 7 years after the epidemic. The model was parameterized with spatial data on QF notifications for the Netherlands, prevalence data from targeted screening studies, and clinical data from the national QF database. The cost-effectiveness of screening varied substantially among subpopulations and geographic areas. Screening that focused on cardiovascular risk patients in areas with high QF incidence during the epidemic ranged from cost-saving to €31,373 per quality-adjusted life year gained, depending on the method to estimate the prevalence of CQF. The cost per quality-adjusted life year of mass screening of all older adults was €70,000 in the most optimistic scenario.
Keywords
Adult, Age Factors, Aged, Aged, 80 and over, Cost-Benefit Analysis, Decision Support Techniques, Female, Humans, Male, Mass Screening/economics, Middle Aged, Netherlands/epidemiology, Prevalence, Q Fever/economics, Young Adult, Journal Article, Research Support, Non-U.S. Gov't
Citation
De Boer, P T, De Lange, M M A, Wielders, C C H, Dijkstra, F, Van Roeden, S E, Bleeker-Rovers, C P, Oosterheert, J J, Schneeberger, P M & Van Der Hoek, W 2020, 'Cost-effectiveness of screening program for chronic q fever, the netherlands', Emerging Infectious Diseases, vol. 26, no. 2, pp. 238-246. https://doi.org/10.3201/eid2602.181772