Log In

Could aging human skin use a connective tissue growth factor boost to increase collagen content?

Files

How and where to find an Open Access version of this publication?

Publication date

2010-02

Authors

Oliver, Noelynn
Sternlicht, Mark
Gerritsen, KarinORCID 0000-0002-1917-6255ISNI 0000000388831038
Goldschmeding, RoelISNI 0000000389519863

Editors

Advisors

Supervisors

DOI

https://doi.org/10.1038/jid.2009.331

Document Type

Article

Metadata

Show full item record

Collections

UMC Repository

License

Abstract

The roles of connective tissue growth factor (CTGF) and transforming growth factor-Β (TGF-Β), both well-known collagen production stimulators, were examined in skin aging. Aged skin and fibroblasts exhibited a coordinate decrease in CTGF, TGF-Β, and type I procollagen expression and content. CTGF knockdown and TGF-Β blockade in normal dermal fibroblasts reduced procollagen expression, whereas overexpressing CTGF increased procollagen by a TGF-Β/Smad signaling-dependent mechanism without involving Smad2/3.

Keywords

Biochemistry, Molecular Biology, Dermatology, Cell Biology

Citation

Oliver, N, Sternlicht, M, Gerritsen, K & Goldschmeding, R 2010, 'Could aging human skin use a connective tissue growth factor boost to increase collagen content?', Journal of Investigative Dermatology, vol. 130, no. 2, pp. 338-341. https://doi.org/10.1038/jid.2009.331

URI

https://dspace.library.uu.nl/handle/1874/457263