Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration
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Publication date
2019
Authors
Smith, Eric E
Biessels, Geert Jan
De Guio, François
de Leeuw, Frank Erik
Duchesne, Simon
Düring, Marco
Frayne, Richard
Ikram, M Arfan
Jouvent, Eric
MacIntosh, Bradley J
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Advisors
Supervisors
Document Type
Article
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cc_by_nc_nd
Abstract
Introduction: Many consequences of cerebrovascular disease are identifiable by magnetic resonance imaging (MRI), but variation in methods limits multicenter studies and pooling of data. The European Union Joint Program on Neurodegenerative Diseases (EU JPND) funded the HARmoNizing Brain Imaging MEthodS for VaScular Contributions to Neurodegeneration (HARNESS) initiative, with a focus on cerebral small vessel disease. Methods: Surveys, teleconferences, and an in-person workshop were used to identify gaps in knowledge and to develop tools for harmonizing imaging and analysis. Results: A framework for neuroimaging biomarker development was developed based on validating repeatability and reproducibility, biological principles, and feasibility of implementation. The status of current MRI biomarkers was reviewed. A website was created at www.harness-neuroimaging.org with acquisition protocols, a software database, rating scales and case report forms, and a deidentified MRI repository. Conclusions: The HARNESS initiative provides resources to reduce variability in measurement in MRI studies of cerebral small vessel disease.
Keywords
Cerebrovascular disease, Dementia, Magnetic resonance imaging, Radiology, Stroke, Journal Article, Review
Citation
Smith, E E, Biessels, G J, De Guio, F, de Leeuw, F E, Duchesne, S, Düring, M, Frayne, R, Ikram, M A, Jouvent, E, MacIntosh, B J, Thrippleton, M J, Vernooij, M W, Adams, H, Backes, W H, Ballerini, L, Black, S E, Chen, C, Corriveau, R, DeCarli, C, Greenberg, S M, Gurol, M E, Ingrisch, M, Job, D, Lam, B Y K, Launer, L J, Linn, J, McCreary, C R, Mok, V C T, Pantoni, L, Pike, G B, Ramirez, J, Reijmer, Y D, Romero, J R, Ropele, S, Rost, N S, Sachdev, P S, Scott, C J M, Seshadri, S, Sharma, M, Sourbron, S, Steketee, R M E, Swartz, R H, van Oostenbrugge, R, van Osch, M, van Rooden, S, Viswanathan, A, Werring, D, Dichgans, M & Wardlaw, J M 2019, 'Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 11, pp. 191-204. https://doi.org/10.1016/j.dadm.2019.01.002