Complete Genome Sequence of the Itraconazole Decreased Susceptible Madurella fahalii Type-Strain CBS 129176
Publication date
2024-02
Authors
Konings, Mickey
Gerrits van den Ende, Bert
Raats, Mirthe W.J.
Fahal, Ahmed Hassan
van de Sande, Wendy W.J.
Hagen, Ferry
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Document Type
Article
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Abstract
Madurella fahalii is a causative agent of the implantation mycosis mycetoma with decreased susceptibility to itraconazole, the preferred therapeutic drug to combat mycetoma. Here, we report the M. fahalii type-strain CBS 129176 genome assembly and annotation to identify a glutamic acid insert near the azole-binding pocket in the Cyp51A protein.
Keywords
De novo genome assembly, Decreased itraconazole susceptibility, Madurella fahalii, Madurella mycetomatis, Nanopore sequencing, Microbiology, Applied Microbiology and Biotechnology, Agronomy and Crop Science, veterinary (miscalleneous)
Citation
Konings, M, Gerrits van den Ende, B, Raats, M W J, Fahal, A H, van de Sande, W W J & Hagen, F 2024, 'Complete Genome Sequence of the Itraconazole Decreased Susceptible Madurella fahalii Type-Strain CBS 129176', Mycopathologia, vol. 189, no. 1, 6. https://doi.org/10.1007/s11046-023-00807-0