Triazacyclophane (TAC)-scaffolded histidine and aspartic acid residues as mimics of non-heme metalloenzyme active sites
Publication date
2012
Authors
Albada, H.B.
Soulimani, F.
Jacobs, H.J.F.
Versluis, Chantal M
Weckhuysen, B.M.
Liskamp, Rob M.J.
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Abstract
We describe the synthesis and coordination behaviour to copper(II) of two close structural triazacyclophane-based mimics of two often encountered aspartic acid and histidine containing metalloenzyme active sites. Coordination of these mimics to copper(I) and their reaction with molecular oxygen leads to the formation of dimeric bis(μ-hydroxo) dicopper(II) complexes.
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Albada, H B, Soulimani, F, Jacobs, H J F, Versluis, C, Weckhuysen, B M & Liskamp, R M J 2012, 'Triazacyclophane (TAC)-scaffolded histidine and aspartic acid residues as mimics of non-heme metalloenzyme active sites', Organic & Biomolecular Chemistry, vol. 10, no. 5, pp. 1088-10921. https://doi.org/10.1039/C1OB06806G