Circular RNAs as Potential Theranostics in the Cardiovascular System
Publication date
2018-12-07
Authors
Bei, Yihua
Yang, Tingting
Wang, Lijun
Holvoet, Paul
Das, Saumya
Sluijter, Joost
Monteiro, Marta Chagas
Liu, Yang
Zhou, Qiulian
Xiao, Junjie
Editors
Advisors
Supervisors
Document Type
Article
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Abstract
Cardiovascular diseases (CVDs) represent the largest contributor to mortality worldwide. Identification of novel therapeutic targets and biomarkers for CVDs is urgently needed. Circular RNAs (circRNAs) are endogenous, abundant, and stable non-coding RNAs formed by back-splicing events. Their role as regulators of gene expression has been increasingly reported. Notably, circRNAs mediate essential physiological and pathological processes in the cardiovascular system. Our first aim, therefore, is to summarize recent advances in the role of circRNAs in cardiac development as well as in pathogenesis of various CVDs. Because circRNAs are stable in circulation and their dynamic changes may reflect different disease stages, they are considered ideal biomarkers. Therefore, our second aim is to review studies that have identified circulating circRNAs as biomarkers for CVDs. Finally, we discuss the shortage of functional studies and the limitations of available clinical studies and provide future perspectives.
Keywords
atherosclerosis, biomarkers, cardiomyopathy, cardiovascular disease, circular RNA, endothelial dysfunction, fibrosis, heart failure, myocardial infarction, therapeutic targets, Molecular Medicine, Drug Discovery
Citation
Bei, Y, Yang, T, Wang, L, Holvoet, P, Das, S, Sluijter, J P G, Monteiro, M C, Liu, Y, Zhou, Q & Xiao, J 2018, 'Circular RNAs as Potential Theranostics in the Cardiovascular System', Molecular therapy. Nucleic acids, vol. 13, pp. 407-418. https://doi.org/10.1016/j.omtn.2018.09.022