Coffee, tea and decaffeinated coffee in relation to hepatocellular carcinoma in a European population: Multicentre, prospective cohort study
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Publication date
2015-04-15
Authors
Bamia, Christina
Lagiou, Pagona
Jenab, Mazda
Trichopoulou, Antonia
Fedirko, Veronika
Aleksandrova, Krasimira
Pischon, Tobias
Overvad, Kim
Olsen, Anja
Tjonneland, Anne
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Document Type
Article
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taverne
Abstract
Inverse associations of coffee and/or tea in relation to hepatocellular carcinoma (HCC) risk have been consistently identified in studies conducted mostly in Asia where consumption patterns of such beverages differ from Europe. In the European Prospective Investigation into Cancer and nutrition (EPIC), we identified 201 HCC cases among 486,799 men/women, after a median follow-up of 11 years. We calculated adjusted hazard ratios (HRs) for HCC incidence in relation to quintiles/categories of coffee/tea intakes. We found that increased coffee and tea intakes were consistently associated with lower HCC risk. The inverse associations were substantial, monotonic and statistically significant. Coffee consumers in the highest compared to the lowest quintile had lower HCC risk by 72% [HR: 0.28; 95% confidence intervals (CIs): 0.16-0.50, p-trend
Keywords
hepatocellular carcinoma, liver cancer, coffee, tea, EPIC, CHRONIC LIVER-DISEASE, RISK-FACTORS, GREEN TEA, CANCER INCIDENCE, CONSUMPTION, JAPAN, DRINKING, ASSOCIATION, EPIDEMIOLOGY, METAANALYSIS, Taverne, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't
Citation
Bamia, C, Lagiou, P, Jenab, M, Trichopoulou, A, Fedirko, V, Aleksandrova, K, Pischon, T, Overvad, K, Olsen, A, Tjonneland, A, Boutron-Ruault, M-C, Fagherazzi, G, Racine, A, Kuhn, T, Boeing, H, Floegel, A, Benetou, V, Palli, D, Grioni, S, Panico, S, Tumino, R, Vineis, P, Bueno-de-Mesquita, H B, Dik, V K, Bhoo Pathy, N, Uiterwaal, C S P M, Weiderpass, E, Lund, E, Quiros, J R, Zamora-Ros, R, Molina-Montes, E, Chirlaque, M-D, Ardanaz, E, Dorronsoro, M, Lindkvist, B, Wallstroem, P, Nilsson, L M, Sund, M, Khaw, K-T, Wareham, N, Bradbury, K E, Travis, R C, Ferrari, P, Duarte-Salles, T, Stepien, M, Gunter, M, Murphy, N, Riboli, E & Trichopoulos, D 2015, 'Coffee, tea and decaffeinated coffee in relation to hepatocellular carcinoma in a European population : Multicentre, prospective cohort study', International Journal of Cancer, vol. 136, no. 8, pp. 1899-1908. https://doi.org/10.1002/ijc.29214