A Neofunctionalized X-Linked Ampliconic Gene Family Is Essential for Male Fertility and Equal Sex Ratio in Mice
Publication date
2019-11-04
Authors
Kruger, Alyssa N.
Brogley, Michele A.
Huizinga, Jamie L.
Kidd, Jeffrey M.
de Rooij, Dirk G
Hu, Yueh Chiang
Mueller, Jacob L.
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Advisors
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Document Type
Article
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taverne
Abstract
A common assumption is that genes essential to a species survival must be deeply conserved. Kruger et al. report how two newly acquired X-linked gene families, Slx and Slxl1, evolved from an autosomal single-copy gene, massively duplicated, became essential for male fertility, and mediated the sex ratio of offspring by gene copy-number changes.
Keywords
gene dosage, male infertility, meiotic drive, X chromosome, Taverne, General Biochemistry,Genetics and Molecular Biology, General Agricultural and Biological Sciences
Citation
Kruger, A N, Brogley, M A, Huizinga, J L, Kidd, J M, de Rooij, D G, Hu, Y C & Mueller, J L 2019, 'A Neofunctionalized X-Linked Ampliconic Gene Family Is Essential for Male Fertility and Equal Sex Ratio in Mice', Current Biology, vol. 29, no. 21, pp. 3699-3706.e5. https://doi.org/10.1016/j.cub.2019.08.057