Multiparametric quantitative MRI assessment of thigh muscles in limb-girdle muscular dystrophy 2A and 2B
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Publication date
2018-10-01
Authors
Arrigoni, Filippo
De Luca, Alberto
Velardo, Daniele
Magri, Francesca
Gandossini, Sandra
Russo, Annamaria
Froeling, Martijn
Bertoldo, Alessandra
Leemans, Alexander
Bresolin, Nereo
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Article
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taverne
Abstract
Introduction: The aim of this study was to apply quantitative MRI (qMRI) to assess structural modifications in thigh muscles of subjects with limb girdle muscular dystrophy (LGMD) 2A and 2B with long disease duration. Methods: Eleven LGMD2A, 9 LGMD2B patients and 11 healthy controls underwent a multi-parametric 3T MRI examination of the thigh. The protocol included structural T1-weighted images, DIXON sequences for fat fraction calculation, T2 values quantification and diffusion MRI. Region of interest analysis was performed on 4 different compartments (anterior compartment, posterior compartment, gracilis, sartorius). Results: Patients showed high levels of fat infiltration as measured by DIXON sequences. Sartorius and anterior compartment were more infiltrated in LGMD2B than LGMD2A patients. T2 values were mildly reduced in both disorders. Correlations between clinical scores and qMRI were found. Conclusions: qMRI measures may help to quantify muscular degeneration, but careful interpretation is needed when fat infiltration is massive. Muscle Nerve 58: 550–558, 2018.
Keywords
diffusion MRI, fat fraction, LGMD2A, LGMD2B, qMRI, T2 quantification, Quadriceps Muscle/diagnostic imaging, Hamstring Muscles/diagnostic imaging, Humans, Middle Aged, Thigh, Adipose Tissue/diagnostic imaging, Male, Muscular Dystrophies, Limb-Girdle/diagnostic imaging, Case-Control Studies, Young Adult, Magnetic Resonance Imaging, Mobility Limitation, Image Processing, Computer-Assisted, Adult, Female, Muscle, Skeletal/diagnostic imaging, Taverne, Clinical Neurology, Physiology (medical), Cellular and Molecular Neuroscience, Physiology, Research Support, Non-U.S. Gov't, Journal Article
Citation
Arrigoni, F, De Luca, A, Velardo, D, Magri, F, Gandossini, S, Russo, A, Froeling, M, Bertoldo, A, Leemans, A, Bresolin, N & D'angelo, G 2018, 'Multiparametric quantitative MRI assessment of thigh muscles in limb-girdle muscular dystrophy 2A and 2B', Muscle & Nerve, vol. 58, no. 4, pp. 550-558. https://doi.org/10.1002/mus.26189