Management of the vertebrae as an organ at risk in paediatric radiotherapy clinical trials: Initial QUARTET experience
Publication date
2023-10
Authors
Turcas, Andrada
Kelly, Sarah M.
Bernier-Chastagner, Valérie
Bolle, Stephanie
Cameron, Alison
Corning, Coreen
Clementel, Enrico
Dieckmann, Karin
Fajardo, Raquel Dávila
Gaze, Mark N.
Editors
Advisors
Supervisors
Document Type
Article
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cc_by_nc_nd
Abstract
Irradiation of the vertebrae in prepubertal patients, if non-homogenous, can result in future growth deformities including kyphoscoliosis. Vertebral delineation and dosimetry were assessed for 101 paediatric cases reviewed within QUARTET-affiliated trials. Despite the availability of published consensus guidelines, a high variability in vertebral delineation was observed, with impact on dosimetry.
Keywords
Clinical trial, Pediatrics, Quality assurance, Radiotherapy, Vertebrae, Hematology, Oncology, Radiology Nuclear Medicine and imaging
Citation
Turcas, A, Kelly, S M, Bernier-Chastagner, V, Bolle, S, Cameron, A, Corning, C, Clementel, E, Dieckmann, K, Davila Fajardo, R, Gaze, M N, Laprie, A, Magelssen, H, Meroni, S, Pignoli, E, Safwat, A, Scarzello, G, Talbot, J, Timmermann, B, Boterberg, T & Mandeville, H C 2023, 'Management of the vertebrae as an organ at risk in paediatric radiotherapy clinical trials : Initial QUARTET experience', Radiotherapy and Oncology, vol. 187, 109810, pp. 1-5. https://doi.org/10.1016/j.radonc.2023.109810