The synthesis of 3-phosphatidyl-1′-glycerol

Abstract

The synthesis of 1-oleoyl-2-palmitoyl glycerol-3-phosphoryl-1′-glycerol is described. By means of a reaction between a 1.2-diacyl-glycerol iodohydrin and the silver salt of 2.3-isopropylidene glycerol-1-(benzyl)-phosphate and removal of the protecting groups phosphatidyl glycerol was obtained in the same stereochemical configuration as the naturally occurring substance. Confirmation of the structure of the synthesized compound was achieved with the aid of different enzymes and analytical procedures.