Ca2+-induced isotropic motion and phosphatidylcholine flip-flop in phosphatidylcholine-cardiolipin bilayers
Publication date
1980-06-06
Authors
Gerritsen, W.J.
Kruijff, B. de
Verkleij, A.J.
Gier, J. de
Deenen, L.L.M. van
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Article
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Abstract
Ca2+ induces a structural change in phosphatidylcholine-cardiolipin bilayers, which is visualised by freeze-fracturing as lipidic particles associated with the bilayer and is detected by 31P-NMR as isotropic motion of the phospholipids. In this structure a rapid transbilayer movement of phosphatidylcholine and a highly increased permeability towards Mn2+ are observed.
Keywords
cardiolipin, phospholipid exchange, transbilayer movement, 31P-NMR, inverted micelle