Evolutionary diversification of defensins and cathelicidins in birds and primates
Publication date
2023-05
Authors
van Dijk, A.
Guabiraba, Rodrigo
Bailleul, Geoffrey
Schouler, Catherine
Haagsman, Henk P
Lalmanach, Anne-Christine
Editors
Advisors
Supervisors
Document Type
Article
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Abstract
Divergent evolution for more than 310 million years has resulted in an avian immune system that is complex and more compact than that of primates, sharing much of its structure and functions. Not surprisingly, well conserved ancient host defense molecules, such as defensins and cathelicidins, have diversified over time. In this review, we describe how evolution influenced the host defense peptides repertoire, its distribution, and the relationship between structure and biological functions. Marked features of primate and avian HDPs are linked to species-specific characteristics, biological requirements, and environmental challenge.
Keywords
Avian, Primate, Defensins, Cathelicidins, Evolution
Citation
van Dijk, A, Guabiraba, R, Bailleul, G, Schouler, C, Haagsman, H P & Lalmanach, A-C 2023, 'Evolutionary diversification of defensins and cathelicidins in birds and primates', Molecular Immunology, vol. 157, pp. 53-69. https://doi.org/10.1016/j.molimm.2023.03.011