On the fate of adenovirus DNA in KB cells

Abstract

Electron microscopic and biochemical studies on the process of infection by adenoviruses have shown that after penetration into the cell the virions lose the pentons and are then gradually uncoated. Later adenovirus DNA is found in the cell nucleus, where DNA replication takes place. The mechanism of replication of linear adenovirus DNA molecules is still unknown. This report presents the first results of a study on the mechanism of adenovirus DNA replication and concerns especially the fate of the parental DNA molecules.