Influence of sulphate on effects of ADP, 3′,5′-cyclic amp and citrate on human platelet phosphofructokinase activity
Publication date
1974-11
Authors
Akkerman, Jan Willem N.
Gorter, G.
Sixma, J.J.
Staal, Gerard E.J.
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Article
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Abstract
1. 1. Sulphate ions activate partially-purified human platelet phosphofructokinase. This is caused by suppression of the cooperativity of the enzyme with respect to fructose 6-phosphate.
2. 2. Sulphate therefore markedly affects the influences of allosteric modifiers such as ADP, 3′,5′-cyclic AMP and citrate.
3. 3. The role of sulphate in assay mixtures is discussed.
Keywords
Phosphofructokinase, platelet, sulphate, citrate, ADP, 3′,5′-cyclic AMP, glycolysis