Concise review: Developing best-practice models for the therapeutic use of extracellular vesicles
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Publication date
2017-08-01
Authors
Reiner, Agnes T.
Witwer, Kenneth W.
Van Balkom, Bas W M
De Beer, Joel
Brodie, Chaya
Corteling, Randolph L.
Gabrielsson, Susanne
Gimona, Mario
Ibrahim, Ahmed G.
de Kleijn, Dominique
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Document Type
Article
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Abstract
Growing interest in extracellular vesicles (EVs, including exosomes and microvesicles) as therapeutic entities, particularly in stem cell-related approaches, has underlined the need for standardization and coordination of development efforts. Members of the International Society for Extracellular Vesicles and the Society for Clinical Research and Translation of Extracellular Vesicles Singapore convened a Workshop on this topic to discuss the opportunities and challenges associated with development of EV-based therapeutics at the preclinical and clinical levels. This review outlines topic-specific action items that, if addressed, will enhance the development of bestpractice models for EV therapies.
Keywords
Cellular therapy, Clinical translation, Clinical trials, Exosomes, Extracellular vesicles, Microvesicles, Stem cells, Therapeutics, Developmental Biology, Cell Biology, Journal Article, Review
Citation
Reiner, A T, Witwer, K W, Van Balkom, B W M, De Beer, J, Brodie, C, Corteling, R L, Gabrielsson, S, Gimona, M, Ibrahim, A G, De Kleijn, D, Lai, C P, Tvall, J L, Del Portillo, H A, Reischl, I G, Riazifar, M, Salomon, C, Tahara, H, Toh, W S, Wauben, M H M, Yang, V K, Yang, Y, Yeo, R W Y, Yin, H, Giebel, B, Rohde, E & Lim, S K 2017, 'Concise review : Developing best-practice models for the therapeutic use of extracellular vesicles', Stem Cells Translational Medicine, vol. 6, no. 8, pp. 1730-1739. https://doi.org/10.1002/sctm.17-0055