Toxicokinetics in fish: Accumulation and elimination of six chlorobenzenes by guppies

Abstract

The kinetics of six chlorobenzenes in guppies has been studied in an accumulation and elimination experiment. Uptake and elimination rate constants and bio-accumulation have been determined and correlated with log Poct. A parabolic curve, with an optimum at log Poct ≈ 5.4, appears to be a better description of the relation of the uptake rate constant with log Poct, than a straight line. The bio-accumulation follows this non-linear behaviour: an optimum has been found at log Poct ≈ 6.5.