In Situ Remodeling Overrules Bioinspired Scaffold Architecture of Supramolecular Elastomeric Tissue-Engineered Heart Valves
Publication date
2020-12
Authors
Uiterwijk, Marcelle
Smits, Anthal I P M
van Geemen, Daphne
Van Klarenbosch, B R
Dekker, Sylvia
Cramer, Maarten J
van Rijswijk, Jan Willem
Lurier, Emily B
Di Luca, Andrea
Brugmans, Marieke C P
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Advisors
Supervisors
Document Type
Article
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License
cc_by_nc_nd
Abstract
In situ tissue engineering that uses resorbable synthetic heart valve scaffolds is an affordable and practical approach for heart valve replacement; therefore, it is attractive for clinical use. This study showed no consistent collagen organization in the predefined direction of electrospun scaffolds made from a resorbable supramolecular elastomer with random or circumferentially aligned fibers, after 12 months of implantation in sheep. These unexpected findings and the observed intervalvular variability highlight the need for a mechanistic understanding of the long-term in situ remodeling processes in large animal models to improve predictability of outcome toward robust and safe clinical application.
Keywords
cell biology/structural biology, valvular heart disease, Cardiology and Cardiovascular Medicine
Citation
Uiterwijk, M, Smits, A I P M, van Geemen, D, van Klarenbosch, B, Dekker, S, Cramer, M J, van Rijswijk, J W, Lurier, E B, Di Luca, A, Brugmans, M C P, Mes, T, Bosman, A W, Aikawa, E, Gründeman, P F, Bouten, C V C & Kluin, J 2020, 'In Situ Remodeling Overrules Bioinspired Scaffold Architecture of Supramolecular Elastomeric Tissue-Engineered Heart Valves', JACC. Basic to Translational Science, vol. 5, no. 12, pp. 1187-1206. https://doi.org/10.1016/j.jacbts.2020.09.011