A Ninhydrin-Type Urea Sorbent for the Development of a Wearable Artificial Kidney
Publication date
2020-03-01
Authors
Jong, Jacobus A.W.
Guo, Yong
Hazenbrink, Diënty H M
Douka, Stefania
Verdijk, Dennis
van der Zwan, Johan
Houben, Klaartje
Baldus, Marc
Scheiner, Karina C
Dalebout, Remco
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Article
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Abstract
The aim of this study is to develop polymeric chemisorbents with a high density of ninhydrin groups, able to covalently bind urea under physiological conditions and thus potentially suitable for use in a wearable artificial kidney. Macroporous beads are prepared by suspension polymerization of 5-vinyl-1-indanone (vinylindanone) using a 90:10 (v/v) mixture of toluene and nitrobenzene as a porogen. The indanone groups are subsequently oxidized in a one-step procedure into ninhydrin groups. Their urea absorption kinetics are evaluated under both static and dynamic conditions at 37 °C in simulated dialysate (urea in phosphate buffered saline). Under static conditions and at a 1:1 molar ratio of ninhydrin: urea the sorbent beads remove ≈0.6-0.7 mmol g-1 and under dynamic conditions and at a 2:1 molar excess of ninhydrin ≈0.6 mmol urea g-1 sorbent in 8 h at 37 °C, which is a step toward a wearable artificial kidney.
Keywords
chemisorption, dialysis, ninhydrin, sorbent, urea, Bioengineering, Materials Chemistry, Polymers and Plastics, Biotechnology, Biomaterials, Journal Article
Citation
Jong, J A W, Guo, Y, Hazenbrink, D, Douka, S, Verdijk, D, van der Zwan, J, Houben, K, Baldus, M, Scheiner, K C, Dalebout, R, Verhaar, M C, Smakman, R, Hennink, W E, Gerritsen, K G F & van Nostrum, C F 2020, 'A Ninhydrin-Type Urea Sorbent for the Development of a Wearable Artificial Kidney', Macromolecular Bioscience, vol. 20, no. 3, 1900396, pp. e1900396. https://doi.org/10.1002/mabi.201900396