Microparticles as biomarkers of osteonecrosis of the hip in sickle cell disease
Publication date
2015-01
Authors
Marsh, Anne
Schiffelers, Raymond
Kuypers, Frans
Larkin, Sandra
Gildengorin, Ginny
van Solinge, Wouter
Hoppe, Carolyn
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Supervisors
Document Type
Article
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Abstract
Osteonecrosis of the femoral head (ONFH) is a common complication of sickle cell disease (SCD). To examine the association between microparticles and ONFH in SCD, we compared plasma microparticle levels in 20 patients with and without ONFH. Microparticles were quantified using nanoparticle tracking analysis and found to be 23-fold higher in patients with ONFH compared to patients without ONFH, and 25-fold higher than in healthy controls. These results suggest that microparticles may be a clinically useful biomarker of ONFH in SCD. Further investigations are needed to determine the functional relevance of microparticles in the pathogenesis of ONFH in SCD.
Keywords
anaemia, sickle cell disease, coagulation, clinical haematology, haemoglobinopathies, FEMORAL-HEAD, LYSOPHOSPHATIDIC ACID, PHOSPHATIDYLSERINE, ANEMIA, Taverne
Citation
Marsh, A, Schiffelers, R, Kuypers, F, Larkin, S, Gildengorin, G, van Solinge, W & Hoppe, C 2015, 'Microparticles as biomarkers of osteonecrosis of the hip in sickle cell disease', British Journal of Haematology, vol. 168, no. 1, pp. 135-138. https://doi.org/10.1111/bjh.13110