CXCL4 suppresses tolerogenic immune signature of monocyte-derived dendritic cells
Publication date
2020-10-01
Authors
Silva-Cardoso, Sandra
Tao, Weiyang
Fernández, Beatriz Malvar
Boes, Marianne
Radstake, Timothy R D J
Pandit, Aridaman
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Abstract
RNA sequencing and DNA methylomic profiling were performed after differentiating monocytes for 6 days into moDCs with/without CXCL4 presence. We show that CXCL4 downregulates genes associated with tolerogenicity in DCs including C1Q. Expression profiles of C1Q genes were negatively correlated with their DNA methylation profiles and with immunogenic genes.
Keywords
C1q, CXCL4, DNA methylation, Monocyte-derived dendritic cells, RNA sequencing, Immunology and Allergy, Immunology, Journal Article
Citation
Silva-Cardoso, S C, Tao, W, Fernández, B M, Boes, M, Radstake, T R D J & Pandit, A 2020, 'CXCL4 suppresses tolerogenic immune signature of monocyte-derived dendritic cells', European Journal of Immunology, vol. 50, no. 10, pp. 1598-1601. https://doi.org/10.1002/eji.201948341