18F-FDG-PET/CT imaging in diagnostic workup of pediatric precursor B-cell lymphoblastic lymphoma
Publication date
2023-11
Authors
Kroeze, Emma
Padilla, Laura Arias
Burkhardt, Birgit
Attarbaschi, Andishe
von Mersi, Hannah
Kebudi, Rejin
Nievelstein, Rutger A J
Tolboom, N.
Hagleitner, Melanie M.
Kuiper, Roland P
Editors
Advisors
Supervisors
Document Type
Article
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taverne
Abstract
18F-fluorodeoxyglucose-positron emission tomography/computed tomography (PET/CT) imaging is currently not used in standard diagnostics for B-cell precursor lymphoblastic lymphoma (BCP-LBL), and it is unknown whether PET/CT imaging would lead to agreement between detection of lesions with the gold standard imaging methods. Therefore, we performed a retrospective cohort study in which we included 32 pediatric BCP-LBL patients and determined localizations by reviewing local imaging reports. There was a disagreement between protocol-based imaging and PET/CT in 59% of the patients, and the discrepancies mostly comprise of additional lesions detected with PET/CT, typically in lymph node and bone or the absence of bone marrow involvement with PET/CT. If PET/CT was leading in determining definite stage of disease, this would lead to a different stage and therapy branch in 31% and 28% of the patients, respectively.
Keywords
F-FDG-PET/CT, B-cell, diagnostics, imaging, lymphoblastic lymphoma, non-Hodgkin lymphoma, PET/CT, Taverne, Pediatrics, Perinatology, and Child Health, Hematology, Oncology, Journal Article, Research Support, Non-U.S. Gov't
Citation
Kroeze, E, Padilla, L A, Burkhardt, B, Attarbaschi, A, von Mersi, H, Kebudi, R, Nievelstein, R A J, Tolboom, N, Hagleitner, M M, Kuiper, R P, Beishuizen, A & Loeffen, J L C 2023, '18 F-FDG-PET/CT imaging in diagnostic workup of pediatric precursor B-cell lymphoblastic lymphoma', Pediatric Blood and Cancer, vol. 70, no. 11, e30642. https://doi.org/10.1002/pbc.30642