Cellular polyploidy in organ homeostasis and regeneration
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Publication date
2023-08-01
Authors
Fang, Juntao
de Bruin, Alain
Villunger, Andreas
Schiffelers, Raymond
Lei, Zhiyong
Sluijter, Joost P G
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Article
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Abstract
Polyploid cells, which contain more than one set of chromosome pairs, are very common in nature. Polyploidy can provide cells with several potential benefits over their diploid counterparts, including an increase in cell size, contributing to organ growth and tissue homeostasis, and improving cellular robustness via increased tolerance to genomic stress and apoptotic signals. Here, we focus on why polyploidy in the cell occurs and which stress responses and molecular signals trigger cells to become polyploid. Moreover, we discuss its crucial roles in cell growth and tissue regeneration in the heart, liver, and other tissues.
Keywords
Humans, Liver, Hepatocytes, Cell Cycle, Polyploidy, Homeostasis
Citation
Fang, J, de Bruin, A, Villunger, A, Schiffelers, R, Lei, Z & Sluijter, J P G 2023, 'Cellular polyploidy in organ homeostasis and regeneration', Protein and Cell, vol. 14, no. 8, pp. 560-578. https://doi.org/10.1093/procel/pwac064