Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis
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Publication date
2019-02-12
Authors
Berkers, Gitte
Van Mourik, Peter
Vonk, Annelotte M
Kruisselbrink, E
Dekkers, Johanna F
de Winter-de Groot, K M
Arets, HGM
Marck-van der Wilt, Rozemarijn E P
Dijkema, Jasper S
Vanderschuren, Maaike M
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Article
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Abstract
Berkers et al. demonstrate that stem cell cultures (organoids) can be a tool for personalized medicine. They show a high correlation between in vitro and in vivo effects of drugs and demonstrate good-to-excellent predictive values of the organoid test for preclinical identification of responders to CFTR modulators.
Keywords
CFTR, cystic fibrosis, drug response, organoids, personalized treatment, predicting, stem cell cultures, Journal Article
Citation
Berkers, G, van Mourik, P, Vonk, A M, Kruisselbrink, E, Dekkers, J F, de Winter-de Groot, K M, Arets, H G M, Marck-van der Wilt, R E P, Dijkema, J S, Vanderschuren, M M, Houwen, R H J, Heijerman, H G M, van de Graaf, E A, Elias, S G, Majoor, C J, Koppelman, G H, Roukema, J, Bakker, M, Janssens, H M, van der Meer, R, Vries, R G J, Clevers, H C, de Jonge, H R, Beekman, J M & van der Ent, C K 2019, 'Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis', Cell Reports, vol. 26, no. 7, pp. 1701-1708.e3. https://doi.org/10.1016/j.celrep.2019.01.068