Induction of Salivary IgA and IgG Responses by Parenteral PPV23 Vaccination in Older Adults
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Publication date
2026-05
Authors
Visser, Maxime
Tcherniaeva, Irina
de Rond, Lia
de Zeeuw-Brouwer, Mary lène
Verschuren, W. M.Monique
Picavet, Susan H.S.J.
de Jonge, Marien I.
den Hartog, Gerco
Buisman, Anne Marie
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Article
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Abstract
Mucosal immunity restricts Streptococcus pneumoniae colonization, thereby reducing the risk of transmission and disease. This is the first study to demonstrate that parenteral 23-valent pneumococcal polysaccharide vaccine (PPV23) vaccination induces salivary IgA and IgG responses in older adults, aged 72–79, an age group at increased risk for pneumococcal disease.
Keywords
antibodies, mucosal immunity, older adults, PPV23, saliva, Oncology, Infectious Diseases
Citation
Visser, M, Tcherniaeva, I, de Rond, L, de Zeeuw-Brouwer, M L, Verschuren, M W M, Picavet, S H S J, de Jonge, M I, den Hartog, G & Buisman, A M 2026, 'Induction of Salivary IgA and IgG Responses by Parenteral PPV23 Vaccination in Older Adults', Open Forum Infectious Diseases, vol. 13, no. 5, ofag273. https://doi.org/10.1093/ofid/ofag273