The Arcuate Fasciculus in auditory-verbal hallucinations: a meta-analysis of diffusion-tensor-imaging studies
Publication date
2014-10
Authors
Geoffroy, Pierre A
Houenou, Josselin
Duhamel, Alain
Amad, Ali
de Weijer, Antoin
Curčić-Blake, Branislava
Linden, David E J
Thomas, Pierre
Jardri, Renaud
Editors
Advisors
Supervisors
Document Type
Article
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taverne
Abstract
Auditory-verbal hallucinations (AVHs) are associated with an impaired connectivity of large-scale networks. To examine the relationship between white-matter integrity and AVHs, we conducted a meta-analysis of diffusion-tensor-imaging studies that compared patients with schizophrenia and AVHs with matched healthy controls (HCs). Five studies were retained gathering 256 DTI data points, divided into AVHs (n=106) and HCs (n=150). The meta-analysis demonstrated a reduced fractional anisotropy in the left Arcuate Fasciculus (AF) of hallucinators (hg= -0.42; CI[-0.69,-0.16]; p<10(-3)). The current meta-analysis confirmed disruptions of white matter integrity in the left AF bundle of schizophrenia patients with AVHs.
Keywords
Anisotropy, Diffusion Tensor Imaging, Hallucinations/pathology, Humans, Subthalamus/pathology, White Matter/pathology, Taverne, Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't
Citation
Geoffroy, P A, Houenou, J, Duhamel, A, Amad, A, De Weijer, A D, Curčić-Blake, B, Linden, D E J, Thomas, P & Jardri, R 2014, 'The Arcuate Fasciculus in auditory-verbal hallucinations : a meta-analysis of diffusion-tensor-imaging studies', Schizophrenia Research, vol. 159, no. 1, pp. 234-237. https://doi.org/10.1016/j.schres.2014.07.014