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Covalent anchoring of a racemization catalyst to CALB-beads: towards dual immobilization of DKR catalysts

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Publication date

2011

Authors

Wieczorek, B.ISNI 0000000395952620
Träff, A.
Krumlinde, P.
Dijkstra, H.P.ISNI 0000000390200630
Egmond, M RISNI 0000000138583836
van Koten, G.ISNI 0000000389131797
Bäckvall, J.-E.
Klein Gebbink, Robertus J.M.ISNI 0000000388707889

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DOI

https://doi.org/10.1016/j.tetlet.2011.01.106

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Article

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Abstract

The preparation of a heterogeneous bifunctional catalytic system, combining the catalytic properties of an organometallic catalyst (racemization) with those of an enzyme (enantioselective acylation) is described. A novel ruthenium phosphonate inhibitor was synthesized and covalently anchored to a lipase immobilized on a solid support (CALB, Novozym® 435). The immobilized bifunctional catalytic system showed activity in both racemization of (S)-1-phenylethanol and selective acylation of 1-phenylethanol.

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Wieczorek, B, Träff, A, Krumlinde, P, Dijkstra, H P, Egmond, M R, van Koten, G, Bäckvall, J-E & Klein Gebbink, R J M 2011, 'Covalent anchoring of a racemization catalyst to CALB-beads: towards dual immobilization of DKR catalysts', Tetrahedron Letters, vol. 52, no. 14, pp. 1601-1604. https://doi.org/10.1016/j.tetlet.2011.01.106

URI

http://hdl.handle.net/1874/212195