The mild stimulation in vitro fertilization protocol

Abstract

There is mounting evidence that the proportion of high-grade or euploid embryo cannot be increased by intensifying ovarian stimulation in IVF. Randomised controlled trials failed to demonstrate improvement in the livebirth rates by administering >150 IU daily dose of gonadotropins. There is no convincing evidence of improved cumulative livebirth with higher stimulation dose. IVF success relates to ovarian response, which correlates with woman’s age and ovarian reserve but not with the intensity of stimulation. Mild ovarian stimulation, defined as less than or equal to 150 IU of daily gonadotropin, adjusted with BMI, may result in equivalent level of success whilst reducing the risk of OHSS and other risks associated with over-response. Mild stimulation IVF is the way forward to make IVF safer, woman-friendly and more affordable.