Ruthenium(II) arene complexes with oligocationic triarylphosphine ligands: synthesis, DNA interactions and in vitro properties
Publication date
2011
Authors
Snelders, D.J.M.
Casini, A.
Edafe, F.
van Koten, G.
Klein Gebbink, R.J.M.
Dyson, P.J.
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Supervisors
Document Type
Article
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Abstract
The synthesis, DNA binding properties and cytotoxicity of a series of Ru(II)-arene complexes containing oligocationic ammonium-functionalized triarylphosphines, of the type Ru(p-cymene)Cl2(L) (L ¼ oligocationic phosphine), are reported. The complexes are highly charged (the overall charge states being þ3 and þ6) and circular dichroism spectroscopy and gel electrophoresis studies indicate that the compounds interact strongly with DNA via electrostatic interactions. Despite forming strong interactions with DNA, the complexes exhibit only modest cytotoxicities on the human ovarian cancer cell lines A2780 and A2780cisR.
Keywords
Bioorganometallic chemistry, Ruthenium, Phosphine ligands, Metal-based drugs, DNA binding, SDG 3 - Good Health and Well-being
Citation
Snelders, D J M, Casini, A, Edafe, F, van Koten, G, Klein Gebbink, R J M & Dyson, P J 2011, 'Ruthenium(II) arene complexes with oligocationic triarylphosphine ligands: synthesis, DNA interactions and in vitro properties', Journal of Organometallic Chemistry, vol. 696, no. 5, pp. 1108-1116. https://doi.org/10.1016/j.jorganchem.2010.11.025