The impact of Bacillus Calmette-Guérin vaccination on antibody response after COVID-19 vaccination
Publication date
2023-11-17
Authors
Taks, Esther J M
Moorlag, Simone J C F M
Föhse, Konstantin
Simonetti, Elles
van der Gaast-de Jongh, Christa E
van Werkhoven, C H
Bonten, Marc J M
Oever, Jaap Ten
de Jonge, Marien I
van de Wijgert, Janneke H H M
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Advisors
Supervisors
Document Type
Article
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cc_by
Abstract
Earlier studies showed that BCG vaccination improves antibody responses of subsequent vaccinations. Similarly, in older volunteers we found an increased IgG receptor-binding domain (RBD) concentration after SARS-CoV-2 infection if they were recently vaccinated with BCG. This study aims to assess the effect of BCG on the serum antibody concentrations induced by COVID-19 vaccination in a population of adults older than 60 years. Serum was collected from 1,555 participants of the BCG-CORONA-ELDERLY trial a year after BCG or placebo, and we analyzed the anti-SARS-CoV-2 antibody concentrations using a fluorescent-microsphere-based multiplex immunoassay. Individuals who received the full primary COVID-19 vaccination series before serum collection and did not test positive for SARS-CoV-2 between inclusion and serum collection were included in analyses (n = 945). We found that BCG vaccination before first COVID-19 vaccine (median 347 days [IQR 329-359]) did not significantly impact the IgG RBD concentration after COVID-19 vaccination in an older European population.
Keywords
health sciences, medical science, microbiology, virology, General
Citation
Taks, E J M, Moorlag, S J C F M, Föhse, K, Simonetti, E, van der Gaast-de Jongh, C E, van Werkhoven, C H, Bonten, M J M, Oever, J T, de Jonge, M I, van de Wijgert, J H H M & Netea, M G 2023, 'The impact of Bacillus Calmette-Guérin vaccination on antibody response after COVID-19 vaccination', iScience, vol. 26, no. 11, 108062. https://doi.org/10.1016/j.isci.2023.108062