Aggregation of different amino acid conjugates of cholic acid in aqueous solution
Publication date
2003-05-29
Authors
Willemen, HM
Vermonden, T
Koudijs, A
Marcelis, ATM
Sudholter, EJR
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Document Type
Article
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Abstract
A series of cholic acid derivatives was synthesized with a variety of alpha-amino acids coupled via an amide bond. These conjugates form aggregates in aqueous solutions. Cryo-transmission electron microscopy (TEM) images show the presence of small micelles with a size of about 5 nm for all compounds. Critical micelle concentration (CMC) values vary slightly with the molecular structure. A small decrease in CMC was found upon increasing the hydrophobicity of the amino acid. The CMC of the tyrosine conjugate showed a small pH-effect, increasing at high pH. (C) 2003 Elsevier Science B.V. All rights reserved.
Keywords
bile acids, micelles, critical micelle concentration, Cryo-TEM, rhodamine 6G, BILE-ACIDS, GLYCINE, SALTS
Citation
Willemen, HM, Vermonden, T, Koudijs, A, Marcelis, ATM & Sudholter, EJR 2003, 'Aggregation of different amino acid conjugates of cholic acid in aqueous solution', Colloids and surfaces. A, physicochemical and engineering aspects, vol. 218, no. 1-3, pp. 59-64. https://doi.org/10.1016/S0927-7757(02)00586-1