Comparative studies on prognostic markers and signaling pathways for canine and human osteosarcoma

Abstract

Osteosarcoma is an aggressive bone tumor that occurs naturally mainly in large and medium breed dogs where almost 90% of dogs will develop metastasis predominantly in the lungs. The standard treatments (extirpation of the primary tumor including limb amputation/sparing, post-operative chemotherapy and palliative radiotherapy) have increased survival rates as compared to denying options for therapy upon diagnosis. Despite the advances in various therapies, prognosis remains poor, with