NaCl Crystals as Carriers for Micronutrient Delivery

Abstract

Iron deficiency leading to anemia is one of the most severe and important nutritional deficiencies in the world today. To combat this deficiency, the fortification of food products with iron is a natural way to increase the global iron uptake. Here, we report a novel strategy for iron encapsulation in NaCl crystals via microscopic inclusions containing dissolved iron salt. The liquid inclusions embedded in the crystal insulate the reactive iron salts from their environment while assuring that iron is in a soluble and bioavailable form. While the size distribution of inclusions remains independent of the evaporation conditions, their density increases during crystallization at lower relative humidity. Using Raman confocal microspectroscopy, we have been able to analyze the morphology, length/thickness ratio, of inclusions and show that inclusions evolve toward a plate-like structure with the increase in size. By growing a pure NaCl shell around the iron-containing NaCl crystals, the stability of the composite crystals can be even further enhanced. The role of halite crystals as a carrier for iron fortification opens the way for the delivery of other types of micronutrients by including them in table salt.