Biologicals as theranostic vehicles in paediatric oncology
Publication date
2022-11-01
Authors
Niessen, Veerle J A
Wenker, Sylvia T M
G. E. H. Lam, Marnix
van Noesel, Max M
Poot, Alex
Editors
Advisors
Supervisors
Document Type
Article
Metadata
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License
cc_by
Abstract
Biologicals, such as antibodies or antibody-fragments e.g. nanobodies, have changed the landscape of cancer therapy and can be used in combination with traditional cancer treatments. They have been demonstrated to be excellent vehicles for molecular imaging. Several biologicals for nuclear imaging of adult cancer may be used in combination with (nuclear) therapy. Though it's great potential, molecular imaging using biologicals is rarely applied in paediatric oncology. This paper describes the current status of biologicals as radiopharmaceuticals for childhood cancer. Furthermore, the importance and potential for developing additional biological theranostics as opportunity to image and treat childhood cancer is discussed.
Keywords
Biologicals, Nuclear imaging, Paediatric oncology, Radionuclide therapy, Theranostics, Molecular Medicine, Radiology Nuclear Medicine and imaging, Cancer Research, Review, Journal Article
Citation
Niessen, V J A, Wenker, S T M, Lam, M G E H, van Noesel, M M & Poot, A J 2022, 'Biologicals as theranostic vehicles in paediatric oncology', Nuclear medicine and biology, vol. 114-115, pp. 58-64. https://doi.org/10.1016/j.nucmedbio.2022.09.001