Identification of a novel genomic island associated with vand-type vancomycin resistance in six Dutch vancomycin-resistant enterococcus faecium isolates
Publication date
2018-03-01
Authors
Top, Janetta
Sinnige, J C
Brouwer, Elisabeth
Werner, Guido
Corander, Jukka
Severin, Juliëtte A.
Jansen, Rogier
Bathoorn, E.
Bonten, Marc J M
Rossen, John W.A.
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Advisors
Supervisors
Document Type
Article
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Abstract
Genomic comparison of the first six Dutch vanD-type vancomycin-resistant Enterococcus faecium (VRE) isolates with four vanD gene clusters from other enterococcal species and anaerobic gut commensals revealed that the vanD gene cluster was located on a genomic island of variable size. Phylogenetic inferences revealed that the Dutch VRE isolates were genetically not closely related and that genetic variation of the vanD-containing genomic island was not species specific, suggesting that this island is transferred horizontally between enterococci and anaerobic gut commensals.
Keywords
Enterococcus faecium, Genomic island, Vancomycin resistance, VanD type, Pharmacology, Pharmacology (medical), Infectious Diseases
Citation
Top, J, Sinnige, J C, Brouwer, E C, Werner, G, Corander, J, Severin, J A, Jansen, R, Bathoorn, E, Bonten, M J M, Rossen, J W A & Willems, R J L 2018, 'Identification of a novel genomic island associated with vand-type vancomycin resistance in six Dutch vancomycin-resistant enterococcus faecium isolates', Antimicrobial Agents and Chemotherapy, vol. 62, no. 3, e01793-17. https://doi.org/10.1128/AAC.01793-17