Neurotoxic effect of the dithiocarbamate tecoram on the chick embryo

Abstract

Tecoram, when administered at doses of 0.01, 0.1, 1 or 10 mg per egg in propylene glycol or in saline to chick embryos caused paralysis, shortening of the extremities, muscular atrophy, dwarfing and death. Microscopically there were signs of peripheral neuropathy, mainly confined to the distal parts of the peripheral nerves, and muscular atrophy. This investigation shows that the chick embryo may be a suitable experimental model for study of the neurotoxic effect of dithiocarbamates.