Steroid monochloroacetates : Physical-chemical characteristics and use in gas-liquid chromatography
Publication date
1965-08
Authors
Molen, H.J. van der
Groen, D.
Maas, J.H. van der
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Document Type
Article
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Abstract
Synthesis and physical-chemical characteristics (melting points, infrared-, visible- and ultraviolet spectra, paper-,thin-layer- and gas-liquid Chromatographie behaviour) of monochloroacetate derivatives of steroids representing the androstane-, pregnane-, estrane- and cholestane series are described. The usefulness of these derivatives in gas-liquid chromatography is demonstrated. Through their strong electron absorbing properties the quantitation of nanogram amounts of these derivatives by electron capture detection is possible.
Keywords
chloroacetate, androsterone, 3α-hydroxy-5α-androstane-17 one, androstenedione, 3β,17α-dihydroxypregn-5-en-20-one, 3-methoxyestra-1,3,5(10)-trien-17β-ol, 3β-hydroxyandrost-5-en-17-one, 5β-pregnane-3α,20α-diol; pregnanolone