Developing a New Stool Test for Colorectal Cancer Screening, the multitargetFIT (mtFIT)
Publication date
2025-05
Authors
de Wit, Meike
Dekker, Evelien
Spaander, Manon
van Leerdam, Monique
Coupe, Veerle
Meijer, Gerrit A
Carvalho, Beatriz
Editors
Advisors
Supervisors
Document Type
Article
Metadata
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License
cc_by_nc
Abstract
Early detection of colorectal cancer (CRC) through screening is the most effective method to reduce morbidity as well as mortality from this disease. Fecal immunochemical test (FIT)-based screening has shown to be effective, especially in multi-round population-based screening. However, its sensitivity and specificity are suboptimal, leaving room for improvement. In this perspective, the development journey of a new screening test, the multitargetFIT (mtFIT), which outperforms FIT, is described from discovery down to large-scale clinical utility testing and health technology assessment.
Keywords
Biomarker development, CRC screening, Fecal immunochemical test (FIT), Multitarget fecal immunochemical test (mtFIT), Physiology, Gastroenterology
Citation
de Wit, M, Dekker, E, Spaander, M, van Leerdam, M, Coupe, V, Meijer, G & Carvalho, B 2025, 'Developing a New Stool Test for Colorectal Cancer Screening, the multitargetFIT (mtFIT)', Digestive Diseases and Sciences, vol. 70, no. 5, pp. 1683-1693. https://doi.org/10.1007/s10620-025-08919-x