Teniposide (VM-26) in patients with advanced refractory ovarian cancer: a phase II study of the Netherlands joint study group for ovarian cancer
Publication date
1987-07
Authors
Burg, M.E.L. van der
Bokkel Huinink, W.W. ten
Vriesendorp, R.
Oosterom, A.T. van
Neijt, J.P.
Vermorken, J.B.
Putten, W.L.J. van
Kooimann, A.
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Article
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Abstract
In 23 evaluable patients with advanced ovarian epithelial cancer refractory to combination therapy with cisplatin and an alkylating agent, teniposide (VM-26) was administered as a short-term i.v. infusion at a dose of 100 mg/m2 on days 1 and 2, every 3 weeks. Toxocity was moderate and comparable to the pattern known from other studies. No objective response has been observed, showing that teniposide is not active as second-line therapy in this disease.