Lateral diffusion of membrane lipids and proteins is increased specifically in neurites of differentiating neuroblastoma cells
Publication date
1979-12-04
Authors
Laat, S.W. de
Saag, P.T. van der
Elson, E.L.
Schlessinger, J.
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Document Type
Article
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Abstract
Lateral diffusion of membrane lipids and proteins was determined in differentiating C1300 mouse neuroblastoma cells by fluorescence photobleaching recovery measurements. It is demonstrated that upon differentiation the lateral diffusion of membrane lipids and proteins is increased specifically in the extending neurites. This indicates the appearance of a topographical heterogeneity in the cell membrane, whereby more fluid domains become located in the membrane of the neurites.
Keywords
lateral diffusion, differentiation, fluidity, membrane lipid, membrane protein, neuroblastoma cell